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In people who are deficient in CYP2D6, coadministration of modafinil with substrates of CYP2D6 that have ancillary routes of elimination via CYP2C19 (eg, tricyclic antidepressants and selective serotonin reuptake inhibitors) may result in elevated circulating amounts of these medications and need dose adjustment (Robertson et al 2000; PROVIGIL® 20
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